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M94A2924.TXT
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1994-10-25
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Document 2924
DOCN M94A2924
TI Subclinical motor deficits in HIV infection are not influenced by
intravenous drug abuse.
DT 9412
AU Giesen HJ; Roick H; Hefter H; Jablonowski H; Freund HJ; Arendt G;
Department of Neurology, University of Dusseldorf, Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):193 (abstract no. PB0199). Unique
Identifier : AIDSLINE ICA10/94369651
AB OBJECTIVE: Electrophysiological evaluation of individual motor
performance is an appropriate means to quantify subclinical motor
deficits in HIV Infection. These deficits may later on result in the HIV
associated cognitive/motor complex. We wanted to find out whether motor
performance is influenced by intravenous drug abuse (IVDA). METHODS:
Most rapid alternating movements (MRAM) and the rise time of most rapid
index finger extension movements (CT = contraction time) as described in
the literature were measured in 114 HIV positive individuals who
acquired HIV either by IVDA (n = 57) or via sexual transmission (n =
57). Both groups were matched for age, time since diagnosis, CD 4 cell
counts and CDC stages (II n = 20, III n = 19, IV n = 18). Results were
compared to those of n = 98 HIV negative healthy controls. RESULTS: Mean
values of MRAM and CT as well as the absolute numbers of pathological
performance were similar without statistically significant differences
between both groups irrespective of the mode of infection. They were
significantly slower (MRAM; p < 0.001 dominant hand) or prolonged (CT; p
< 0.001 dominant hand) than in the controls. DISCUSSION AND CONCLUSIONS:
Intravenous drug abuse despite its possible influence on the central
nervous system does not interfere with the HIV-induced changes of motor
performance.
DE AIDS Dementia Complex/DIAGNOSIS/*PHYSIOPATHOLOGY Human
Laterality/PHYSIOLOGY Motor Skills/*PHYSIOLOGY Muscle
Contraction/PHYSIOLOGY *Neurologic Examination Neuromuscular
Diseases/DIAGNOSIS/*PHYSIOPATHOLOGY Reaction Time/PHYSIOLOGY Reference
Values Substance Abuse, Intravenous/COMPLICATIONS/*PHYSIOPATHOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).